Expression of cytoskeletal binding protein 4. 1N in Ewing's sarcoma and its clinical significance
10.13315/j.cnki.cjcep.2018.06.007
- VernacularTitle:尤因肉瘤中细胞骨架结合蛋白4.1N的表达及其临床意义
- Author:
Wei-Wen ZHANG
1
;
Xiao-Ting ZHOU
;
Fei GAO
;
Xiu-Li AN
;
Hua WANG
Author Information
1. 北京大学医学部病理学系/北京大学第三医院病理科
- Keywords:
Ewing's sarcoma;
4. 1N;
Ki-67;
immunohisto-chemistry;
clinicpathologic features
- From:
Chinese Journal of Clinical and Experimental Pathology
2018;34(6):619-623
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of cy-toskeletal protein 4. 1N in Ewing's sarcoma and the correlation with cell proliferation as well as clinicopathological characteris-tics. Methods Immunohistochemical EnVision two-step stai- ning was used to detect the expression of 4. 1N in 52 Ewing's sarcoma cases, which 47 cases of them were performed to detect the expression of Ki-67. The relationship between the expression of 4. 1N and Ki-67, and the correlation with the pathological fea- tures including prognosis were analyzed. Results The positive expression of 4. 1N was found in 35% (18/52) of Ewing's sar-coma. Lower frequency of 4. 1N strong expression (1. 9% , 1/52) was detected in the cohort. Ki-67 labeling index in Ewing's sarcoma varied from 3% to 85% . 4. 1N expression displayed a negative correlation with Ki-67 index ( P ＜0. 05). Among the follow-up of 27 cases, Kaplan-Meier survival analysis suggested that patients with 4. 1N-negative had shorter survival period than patients with 4. 1N positive expression (P ＜0. 05). However, the expression of 4. 1N was not statistically correlated with sex, age, tumor's localization and metastasis. Conclusion 4. 1N mainly showed negative or lower expression in Ewing's sarcoma and was related to cell proliferation index Ki-67, which implied a potential function in regulating proliferation in Ewing's sarcoma. 4. 1N expression has potentially predictive value in outcome of E-wing's sarcoma.
