Ganglioglioma: a clinicopathological study of 19 cases
10.13315/j.cnki.cjcep.2018.03.008
- VernacularTitle:神经节细胞胶质瘤19例临床病理分析
- Author:
Le LIANG
1
;
Jing FU
;
Da-Sheng LI
;
Hui LENG
;
Yong-Ling LIU
;
Xiao-Xiang YAO
;
Ri-Le GE
;
Yun-Lin LI
;
Kang-Ping MA
Author Information
1. 北京市海淀医院/北京大学第三医院海淀院区病理科、北京 100080
- Keywords:
brain neoplasm;
ganglioglioma;
focal cortical dysplasia
- From:
Chinese Journal of Clinical and Experimental Pathology
2018;34(3):273-278
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the clinicopathologic features of ganglioglioma. Methods The clinicopathologic data of the cases pathologically diagnosed as ganglioglioma that underwent resection of epileptic focus were retrospectively analyzed. Results In the 19 cases studied, the mean onset age was 9.1 years, and the duration of disease was 9.3 years. MRI images showed abnormal signals. The majority of the site was temporal lobe (14/19, 73.7％). The tumors showed heterogeneity and often accompanied by focal cortical dysplasias (13/19, 68.4％). Immunohistochemical staining showed CD34 positive in 18 cases, Nestin positive in 16 cases, and BRAF-V600E positive in 6 case. The positive expression rate of CD34 and Nestin did not have significant differences. Conclusion The diagnosis of ganglioglioma relies on pathological observations combined with clinical features and neuroradiological examinations. Differential diagnosis should be done from other tumors or cortical dysplasia. Immunohistochemical staining of CD34 and Nestin can help diagnosis.
