Clinicopathologic features of mammary analogue secretory carcinoma of salivary glands
10.13315/j.cnki.cjcep.2018.02.014
- VernacularTitle:涎腺分泌性癌4例临床病理特征
- Author:
Lei ZHANG
1
;
Jian-Guo WEI
;
Mei XU
;
Ling-Fei KONG
Author Information
1. 河南省人民医院病理科
- Keywords:
salivary gland neoplasms;
mammary analogue secretory carcinoma;
secretory carcinoma;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2018;34(2):187-190
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To summarize the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of mammary analogue secretory carcinoma of salivary glands(MASC). Methods Four cases of MASC were included. The clinical, histological, and immunohistochemical features and follow-up data were evaluated. Results The patients aged between 20 to 72 years. Two cases were male and two were female. The average age was 52.2 years. All cases showed infiltrative growth and diverse cytology and histology, including lobular, cystic papillary, solid, cribriform or glandular structures, and microcystic honeycombed pattern composed of small cysts merged into larger cysts resembling thyroid follicles. There were no necrosis, nerve or vascular invasion in 4 cases. S-100 protein, Mammaglobin or SOX10 were strongly positive in all MASC cases.3 cases were insignificant positivity for GATA-3. Both p63 and DOG-1 were negative. Conclusion MASC is a lowgrade malignant epithelial tumor of salivary glands. Combined immunohistochemical positivity of S-100 protein, Mammaglobin and SOXIO, or negative for DOG-1, are useful in the diagnosis and differential diagnosis of MASC.
