Expression of SEL1L and BCL-2 in diffuse large B cell lymphoma
10.13315/j.cnki.cjcep.2018.02.007
- VernacularTitle:弥漫大B细胞淋巴瘤中SEL1L、BCL-2的表达及意义
- Author:
Yan SHU
1
;
He-Qin ZHAN
;
Meng-Meng LIU
;
Rong QIN
;
Gang MENG
Author Information
1. 安徽医科大学基础医学院病理学教研室
- Keywords:
lymphoma;
diffuse large B cell lymphoma;
SEL1L;
BCL-2
- From:
Chinese Journal of Clinical and Experimental Pathology
2018;34(2):153-157
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression and the clinical significances of SEL1L and BCL-2 in 123 cases of diffuse large B cell lymphoma (DLBCL) and cell line SUDHL-4, LY-10. Methods Immunohistochemistry staining for SEL1L was performed in 123 DLBCL and 60 reactive lymphoid hyperplasia (RLH), and also BCL-2 protein in 123 DLBCL. Immunocytochemistry staining and Western blot analysis for SEL1L protein were used in SUDHL-4 and LY-10. Results The high expression rate of SEL1L was 69.9％ in 123 DLBCL, which was significantly higher than that in 60 RLH (25.0％ ). The expression of SEL1L protein in DLBCL was not related to clinic pathological parameters. The positive rate of BCL-2 was 83.7％ in123 DLBCL. The expression of BCL-2 protein was correlated with immunophenotyping, primary location, and Ann Arbor stage. The expression of SEL1L protein was positively correlated with that of BCL-2 protein in DLBCL (r=0.227, P＜0.05). SEL1L protein was also detected in SUDHL-4 and LY-10 cell lines. Conclusion The SEL1L protein may play an important role in the carcinogenesis of DLBCL, and may be associated with BCL-2.
