Clinicopathological analysis of 5 cases of placental mesenchymal dysplasia
10.13315/j.cnki.cjcep.2018.01.013
- VernacularTitle:胎盘间叶发育不良5例临床病理分析
- Author:
Yang ZHAN
1
;
Xing-Zheng ZHENG
;
Cheng-Hong YIN
;
Yu-Chun GU
;
Li ZHU
Author Information
1. 首都医科大学附属北京妇产医院病理科
- Keywords:
placental mesenchymal dysplasia;
villous edema;
non-hydatidiform pregnancy;
differential diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2018;34(1):55-59
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinicopathological features, diagnosis, differential diagnosis and prognosis of placental mesenchymal dysplasia. Method The clinicopathological data of 5 cases with placental mesenchymal dysplasia were retrospectively analysed and related literatures were also re-viewed. Results All of 5 patients were consciously fetal movement disappeared or found abnormal ultrasound results at routine examination of the pregnancy. The placentas were enlarged, partly with oedematous "grape-like" cysts. On histologic exami-nation, enlarged villi with varying degrees of edema contained abnormal thick walled fetal blood vessels. The chorionic vessels were expanded and congested, and some chorionic villi showed mesenchymal cell hyperplasia. In immunohistochemical staining, p57 was positive, and Ki-67 showed low expression. There was no the trophoblastic proliferation. It's mainly differential diagnosis was hydatidiform mole.2 cases were accompanied with stillbirth. Conclusion The diagnosis of placental mesenchymal dysplasia can be confirmed by pathology examination. When a cystic placenta is detected by ultrasound examination, placental mesenchymal dysplasia should be considered in the differential diagnosis.
