Sinonasal mammary analogue secretory carcinoma: a clinicopathological analysis of 2 cases
10.13315/j.cnki.cjcep.2018.01.009
- VernacularTitle:鼻腔鼻窦原发分泌性癌2例临床病理学观察
- Author:
Chang-Li YUE
1
;
Ge-Hong DONG
;
Xiao-Li ZHAO
;
Yi-Ding HAN
;
Yi-Hua ZHAO
;
Hong-Gang LIU
Author Information
1. 首都医科大学附属北京同仁医院病理科/头颈部分子病理诊断北京市重点实验室
- Keywords:
sinonasal neoplasm;
secretory carcinoma;
clinical pathology;
differential diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2018;34(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features of sinonasal primary secretory carcinoma (SC) and its diagnosis, differential diagnosis. Methods Two cases of sin-nasal SC were analyzed by light microscopy with immunohisto-chemical staining (EnVision) for CK, vimentin, S-100 protein, SOX10, PAS, DPAS, Mamaglobin, Calponin, DOG1, p63 and molecular detection of ETV6 gene break. Results Morphologically, SC revealed varying proportions of solid, tubular, acinar, microcystic, tubular growth patterns. All SC cases were cytological low grade with uniform cells, small-to medium-sizes nuclei, occasional small nucleoli, and abundant pink, bubbly cytoplasm. Mitotic figures were rarely encountered. Tumor cells secreted eosinophilic, colloid-like secretions that were PAS positive. There were no DPAS positive zymogen granules in cyto-plasm. This tumor cells were CK, vimentin, S-100, SOX10, PAS positive and Mamaglobin, Calponin and p63 negative. The ETV6 gene rearrangement was confirmed in all cases by fluorescence in situ hybridization (FISH). After excision, all two patients were survival without tumor recurrence for 41 months and53 months. Conclusion Sinonasal primary SC is a low grade malignant tumor. The histological features of SC are overlap with other salivary gland tumors. Immunohistochemical analysis and FISH are useful for the diagnosis and differential diagnosis.
