Changes of histopathology and molecular indicators in breast cancer after neoadjuvant chemotherapy
10.13315/j.cnki.cjcep.2018.01.004
- VernacularTitle:乳腺癌新辅助化疗前后病理组织学及分子指标变化
- Author:
Hong-Ping TANG
1
;
Lei RONG
;
Guan-Nan LIANG
;
Guo-Yan CHEN
;
Xin WEI
;
Xin-Yi HUANG
Author Information
1. 南方医科大学附属深圳妇幼保健院 病理科 深圳 518028
- Keywords:
breast neoplasm;
neoadjuvant chemotherapy;
pathology;
molecular indicator
- From:
Chinese Journal of Clinical and Experimental Pathology
2018;34(1):12-15
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the changes of histopathology and expression levels of ER, PR, HER-2 and Ki-67 in breast cancer after neoadjuvant chemotherapy (NTC), and to evaluate the relationship between the curative effect and clinico-pathological characteristics of breast cancer. Methods 93 ca-ses of invasive breast cancer with NTC were collected and retro-spectively analyzed. Pathologic evaluation of chemotherapeutic effect were evaluated by Miller-Payne (MP) grading system. Results Tumor cells, tumor stroma and lymph nodes status presented different histopathological changes after NTC. There were significant relationship between curative effect and patients age (Z=-1.993, P=0.046 ), histological grade (χ2=7.261, P=0.027), molecular subtypes (χ2=8.289, P=0.040), while it had no statistical relationship between curative effect and tumor size (Z=-1.091, P=0.275) and lymph node status (Z=-1.107, P = 0.268). Expression of ER, PR, HER-2 and Ki-67 showed different degrees of change before and after NTC. The concordance rates of ER, PR, HER-2 and Ki-67 were 81.0％, 72.2％, 83.5％ and 55.7％, respective-ly. And there was no significant difference in expression of these four molecular indicators before and after NTC (χ2 =0.428, P=0.934). Conclusion The histomorphology of tumor cell, tumor stroma and lymph node status can be influenced by NTC. Objective evaluation of the changes of histopathology and molecular indicators after NTC may valuable in predicting clinical prognosis and guiding individual treatment of breast cancer.
