Expression of FLi-1, h-caldesmon and collagen Ⅳ in glomus tumor: a clinicopathologic study
10.13315/j.cnki.cjcep.2017.12.010
- VernacularTitle:血管球瘤中FLi-1、h-caldesmon及collagen Ⅳ的表达及临床病理分析
- Author:
Yong YANG
1
;
Rui-Lin WANG
;
Jin XU
;
Hai-Bo YIN
Author Information
1. 天津市天津医院病理科
- Keywords:
soft tissue neoplasms;
glomus tumor;
FLi-1;
h-caldesmon;
collagen Ⅳ;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(12):1337-1341
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the expression of FLi-1,h-caldesmon and collagen Ⅳ in glomus tumor and possible relationship between different histological types and clinical-pathological characteristics.Methods Immunohistochemistry of EnVision method was used to detect the expression of FLi-1,h-caldesmon and collagen Ⅳ in 35 cases of glomus tumor under microscope,and the relationship between different histological types and clinical-pathological characteristics was analyzed.Results The pathological morphology of tumor cells was round or polygonal,patchy distribution in blood vessels or arranged in a ring around the blood vessels.The tumor cell boundary was clear and the shape was regular,gradual transition between tumor cells and spindle smooth muscle cells was sometimes visible.The positive rate of FLi-1,h-caldesmon and collagen Ⅳ in 35 cases of glomus tumor were 58.6％,97.1％ and 100％ respectively.Different histological types of glomus tumors had no correlation with the sex of patient and the size of tumor,but had correlation with the age of patient.Vimentin and SMA were positive for glomus tumors by immunohistochemistry in 35 cases.CD34 was positive in 2 cases.Desmin positive was found in 1 case.EMA,S-100,CgA,CD68 and CD99 were negative.Conclusion h-caldesmon and collagen Ⅳ are the markers for glomus tumor diagnosis,and FLi-1 can serve as a good auxiliary reference marker.
