Significance of TNFAIP3 abnormity in natural killer/T-cell lymphoma, nasal type detected by fluorescence immunophenotyping and interphase cytogenetics

VernacularTitle:联合免疫荧光和荧光原位杂交法检测TNFAIP3基因在结外鼻型NK/T细胞淋巴瘤中的异常及意义
Author: Fang LIU ¹ ; Ying-Mei WANG ; Ming-Yang LI ; Dan-Hui ZHAO ; Xia LI ; Yi-Xiong LIU ; Zhe WANG ; Qing-Guo YANG
Author Information

1. 第四军医大学病理学教研室
Keywords: lymphoma; nasal type natural killer/T-cell lymphoma; TNFAIP3; FICTION
From: Chinese Journal of Clinical and Experimental Pathology 2017;33(12):1307-1310
CountryChina
Language:Chinese
Abstract: Purpose To explore the prognostic value of deletion of the TNFAIP3 gene in natural killer/T-cell lymphoma,nasal type detected with fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasm (FICTION).Methods FICTION was performed to detect the abnormalities of TNFAIP3 gene in 109 cases of natural killer/T-cell lymphoma,nasal type.Results TNFAIP3 deletion was found in 25/79 detectable cases.The deletion of TNFAIP3 was positively correlated with the International Prognosis Index (IPI) (P =0.019).Conclusion Frequent deletion of TNFAIP3 was associated with IPI in natural killer/T-cell lymphoma,nasal type,suggesting the important prognostic value of TNFAIP3 in the natural killer/T-cell lymphoma,nasal type.