Clinical significance of expression of eIF-4E and p-4EBP-1 protein in the gastric carcinoma
10.13315/j.cnki.cjcep.2017.10.004
- VernacularTitle:胃癌组织中eIF-4E和p4EBP-1蛋白表达的临床意义
- Author:
Jun ZHENG
1
;
Chun-Yan ZHANG
;
Yi-Qiang ZHANG
;
Li-Li MA
;
Jin-Hong PEI
Author Information
1. 长治医学院生化教研室
- Keywords:
gastric neoplasms;
eIF-4E;
p-4EBP-1
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(10):1078-1081
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of eIF-4E and p-4EBP-1 and its clinical significance in the gastric carcinoma.Methods Expression of eIF-4E and p-4EBP-1 was detected in tissue array including 168 cases of gastric carcinoma and 52 cases of peri-cancer tissues by immunohistochemical SP method.Results The positive expression of eIF-4E and p-4EBP-1 in the gastric carcinoma was significantly higher than that of peri-cancer tissues (P =0.001,P =0.000).There was significantly higher expression of eIF-4E and p-4EBP-1 with lymph node metastases than without lymph node metastases in the gastric carcinoma (P =0.025,P =0.001).Also,there was significantly higher expression of eIF-4E and p-4EBP-1 with clinical stages Ⅲ + Ⅳ than that of stages Ⅰ + Ⅱ (P =0.001,P=0.049).In addition,there was a significantly positive correlation between the expression of eIF-4E and p-4EBP-1 in the gastric carcinoma (r =0.432,P ＜ 0.01).The overall survival rates for patients with negative expression of eIF-4E protein was higher than that with positive expression (P =0.012).Conclusion The abnormal co-expression of eIF-4E and p-4EBP-1 may be related to the tumorgenesis,development,metastasis and invasion of gastric carcinoma,and eIF-4E and p-4EBP-1 may act as the new molecular targets for the therapy and diagnosis of gastric carcinoma.
