The effect of structured lipid emulsion on cellular immune function in patients with gastrointesti-nal cancer after operation
10.3969/j.issn.1005-6483.2018.05.023
- VernacularTitle:结构脂肪乳对胃肠道肿瘤病人术后细胞免疫功能的影响
- Author:
Guizhen ZOU
1
;
Kai WEI
Author Information
1. 430014,华中科技大学附属武汉市中心医院胃肠痔瘘外科
- Keywords:
gastrointestinalcarcinoma;
structured lipid emulsion;
cellular immune
- From:
Journal of Clinical Surgery
2018;26(5):390-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of structured lipid emulsion on cellular immune function in patients with gastrointestinal cancer after operation. Methods 76 cases of gastrointestinal cancer patients were chosen as the research object.The patients were divided into the control group and the experimental group according to the nutrition support after the operation,38 cases in each group.The experimental group used 20% structural lipid emulsion injection(medium chain fat milk accounted for 36%,long chain fat milk accounted for 64%,250 ml/ bottles),the control group used 20% physically mixed medium / long chain fat milk(medium chain fat milk and long chain fat milk accounted for 50%, respectively,250 ml/ bottles),and then compared the immune function index of the two groups.Results Immune function index of CD3 +at preoperative,third days and sixth days after the operation in the experi-mental group were 65.92 ± 4.71,60.62 ± 6.33 and 66.51 ± 3.58,respetively.While in the control group were 65.77 ± 4.63,57.86 ± 6.11 and 60.04 ± 3.21.Immune function index of CD4 +at preoperative, third days and sixth days after the operation in the experimental group were 43.75 ± 6.37,38.44 ± 5.68 and 47.98 ± 3.22,respectively.While in the control group were 43.26 ± 6.18,35.32 ± 6.78 and 37.93 ± 7.15,respectively.Immune function index of CD8 +at preoperative,third days and sixth days after the operation in the experimental group were 23.85 ± 7.16,21.96 ± 7.45 and 23.67 ± 5.47,respectively. While in the control group were 23.36 ± 6.69,21.43 ± 7.02 and 22.54 ± 6.12,respectively.Immune function index of CD4 +/CD8 +at preoperative,third days and sixth days after the operation in the experi-mental group were 1.86 ± 0.35,1.72 ± 0.39 and 1.99 ± 0.56,respectively.While in the control group were 1.83 ± 0.31,1.66 ± 0.32 and 1.68 ± 0.41,respectively.Immune function index(CD3 +,CD4 +and CD4 +/CD8 +)in the experimental group were significantly higher than those in the control group after sixth days(P< 0.05).Conclusion Postoperative early structured lipid emulsion nutrition support can correct the immune suppression in patients with gastric intestinal cancer,and improve cellular immune function.
