The Differences in Second Trimester Quad Test Markers in Patients with Severe Preeclampsia Depending on the Disease Onset Time and the Presence of Fetal Growth Restriction.
- Author:
Hyun Sook AHN
1
;
Il Jung CHOI
;
So Young LEE
;
Moon Jung KIM
;
Hee Jin KIM
;
Moon Seok CHA
;
Ji Young KANG
;
Myeung Seok HAN
Author Information
1. Department of Obstetrics and Gynecology, Dong-A University, College of Medicine, Busan, Korea. iljung11@dau.ac.kr
- Publication Type:Original Article
- Keywords:
Quad test markers;
Preeclampsia;
Fetal growth restriction;
Early onset;
Late onset
- MeSH:
Adenine;
alpha-Fetoproteins;
Carbamates;
Chorionic Gonadotropin;
Deoxycytidine;
Drug Combinations;
Estriol;
Female;
Fetal Development;
Humans;
Organophosphonates;
Pre-Eclampsia;
Pregnancy;
Pregnancy Trimester, Second;
Quinolones;
Retrospective Studies;
Thiazoles;
Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
- From:Korean Journal of Perinatology
2010;21(2):147-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To compare the differences in the second trimester Quad test markers in patients who subsequently developed preeclampsia depending on the disease onset time and the presence of fetal growth restriction (FGR). METHODS: A retrospective study was carried out on 66 women with severe preeclampsia and 345 controls who were delivered at Dong-A University hospital and Ilsin Christian Hospital from January 2006 to December 2008. Severe preeclampsia patients were grouped according to with (n=30) or without (n=36) FGR. Severe preeclampsia patients were also grouped according to early onset (n=16) or late onset (n=50) The levels of the second trimester human chorionic gonadotropin (hCG), inhibin-A, unconjugated estriol (uE3), alpha-fetoprotein (AFP) were compared in each group. RESULTS: In the pregnancies that subsequently developed severe preeclampsia, the second trimester hCG, inhibin-A and AFP were significantly higher than the controls. We found that levels of hCG, inhibin-A in severe preeclampsia complicated by FGR were significantly higher than those without FGR. We also found that levels of AFP and inhibin-A in early onset severe preeclampsia were significantly higher than late onset severe preeclampsia. CONCLUSION: The levels of second trimester Quad test markers in patients that subsequently developed severe preeclampsia were different according to with or without FGR and onset time.
