Comparison of application of different etomidate-propofol concentrations for painless gastroscopy
10.12089/jca.2018.03.009
- VernacularTitle:不同配比依托咪酯-丙泊酚混合液在无痛胃镜中的应用比较
- Author:
Xiaochun YANG
1
;
Yongqiu XIE
;
Wanying ZHAO
;
Huan LIU
;
Aiguo YANG
;
Xinran HOU
;
Qulian GUO
Author Information
1. 中南大学湘雅医院麻醉科
- Keywords:
Etomidate;
Propofol;
Gastroscopy;
Sedation
- From:
The Journal of Clinical Anesthesiology
2018;34(3):246-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the anesthetic effects,safety and side effects of the mixture with different ratios of etomidate to propofol in painless gastroscopy.Methods Two hundred patients scheduled for painless gastroscopy,95 males and 105 females,aged 18 to 65 years,BMI 18.5-27.0 kg/m2,ASA physical status Ⅰ or Ⅱ,were randomized into two groups,group A (the ratio of eto-midate and propofol volume 1:1);group B (the ratio of etomidate and propofol volume 1:2).All of the patients were injected with sufentanil 0.1 μg/kg at first.All patients were given the first dose of 0.15-0.2 ml/kg intravenously slowly.Repeated doses of 1-2 ml etomidate-propofol were administered to maintain an adequate level of sedation.HR,SBP,DBP and SpO2were monitored.The dosages of etomidate and propofol were recorded.At the same time the induction time,the operation time,the recovery time and the leaving time were recorded.And low blood pressure,hypoxia saturation,re-spiratory obstruction,muscle fibrillation,nausea and vomiting and other adverse reactions were re-corded.Results There was no significant difference between group A and group B in the induction time,the operation time,the recovery time,the leaving time,perioperative hypotension,periopera-tive hypoxia and injection pain.The dosage of etomidate in the group A was significantly more than in the group B (P<0.01).The dosage of propofol in the group A was significantly less than in the group B(P<0.05).The incidence of myoclonus in group A was notably higher than that in the group B (P<0.01),The incidence of nausea and vomiting in group A was higher than that in the group B (P<0.05).Conclusion Etomidate plus propofol (1:2)had less incidence of myoclonus and nausea and vomiting,and it is more suitable for gastroscopy than 1:1 EP mixture.
