Changes of serum C-X-C motif ligand 13 concentration in senior patients undergoing total hip replacement
- VernacularTitle:老年患者髋关节置换术后血清趋化因子CXC配体13的变化
- Author:
Yanna SI
1
;
Hongguang BAO
;
Xiaoliang WANG
;
Yajie XU
;
Ling JING
;
Lingqing ZENG
;
Yuan GENG
Author Information
- Keywords: POCD; Senior patients; Inflammatory reaction; Chemokine; CXCL13
- From: The Journal of Clinical Anesthesiology 2018;34(3):230-233
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the changes of serum C-X-C motif ligand 13 (CXCL13) concentration in senior patients undergoing total hip replacement and its role in post-operative dys-function(POCD).Methods Eighty consecutive senior patients aged 65-80 years with BMI 18.4-27.3 kg/m2,ASA physical status Ⅱ or Ⅲ,were recruited and scheduled to undergo hip joint replacement operation.Neuropsychological test was performed 1-5 d after operation and patients were divided into POCD group and non-POCD group.Serum C reactive protein (CPR),procalcitonin (PCT),IL-6, TNF-α,CXCL13 concentration were detected 1 d before and 1,2,3,4,5 d after operation. Results A total of 21 (26%)patients developed POCD 1-5 d after operation (recruited in POCD group),and the other 59 patients were recruited in non-POCD group.Compared with the time point of 1 d before operation,serum CRP,PCT,IL-6,TNF-αand CXCL13 concentration were higher 1-5 d after operation in all patients (P<0.05).The concentrationsof these factors were higher in patients from POCD group than in those from non-POCD group 1-5 d after operation (P < 0.05). Conclusion The CXCL13 concentration insenior patients undergoing total hip replacement who devel-oped POCD were higher than in those who did not developed POCD.Whether it is correlated with POCD remains further study.
