Effect of anesthetic sensitivity to propofol after biliary decompression in common bile duct ligation rats
10.12089/jca.2018.01.016
- VernacularTitle:梗阻性黄疸大鼠胆总管再通对丙泊酚麻醉敏感性的影响
- Author:
Hao GAO
1
;
Jinchao SONG
;
Mazhong ZHANG
;
Yang BAO
;
Jinmin ZHANG
;
Weifeng YU
Author Information
1. 第二军医大学附属东方肝胆外科医院麻醉科
- Keywords:
Reversible obstructive jaundice;
Propofol;
Anesthesia sensitivity
- From:
The Journal of Clinical Anesthesiology
2018;34(1):67-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate if anesthetic sensitivity to propofol will be restored after biliary decompression.Methods Twenty-four adult male SD rats were randomly assigned into 3 groups:sham group (group S),irreversible obstructive jaundice group (group Ⅰ) and reversible obstructive jaundice group (group R).The serum total bilirubin (TBL) and total bile acid (TBA) concentratins were detected in the rat blood samples collected from the caudal vein before and after the operation,3,7,14,21 d respectively.Propofol was administered to measure the time of loss of righting reflex and recovery pre or 7th and 21th day post ligation.Results Serum TBL and TBA in group Ⅰ and serum TBA in group R were significantly higher than that in group S on 3rd,7th,14th,21th day post surgery(P＜0.05).Compared with group S,seum TBL in group R were significantly high on 3rd,7th,14th day post-surgery.Serm TBL and TBA in group R were significantly lower than group Ⅰ on 14th,21th day post-surgery (P＜0.05).Compared with group S,the time to loss of righting reflex in group I and group R were significantly shortened and the time to recovery were significantly increased on 7th day post-surgery (P＜0.05).Conclusion Obstructive jaundice could significantly potentiate the ability of propofol to induce a loss of righting reflex,and the increased anesthesia sensitivity will be restored after biliary decompression.
