Frequency of aneathetics-related genetic polymorphism in the North-western Chinese population
- VernacularTitle:中国西北部地区汉族患者麻醉药物相关基因多态性的分布
- Author:
Guanglin LIU
1
;
Zhihong LU
;
Min CHEN
;
Jieru WANG
;
Huang NIE
;
Hailong DONG
Author Information
1. 西京医院麻醉科
- Keywords:
Genetic polymorphism;
North-western China;
Han population;
Frequency
- From:
The Journal of Clinical Anesthesiology
2017;33(12):1149-1151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence of genotypes related to analgesia and muscle relax effects,and to review the genetic polymorphism of OPRM1,CYP3A4 * 1G,SLCO1B1 and ABCB1 in Han population in North-western China.Methods The genotypes of OPRM1,CYP3A4 * 1G,SLCO1B1 and ABCB1 in patients born in North-western China between September,2016 and May,2017 were reviewed.North-western China was defined as Shaanxi,Gansu,Ningxia,Qinghai and Xinjiang Provinces.The distribution of genotypes was recorded.And the differences between male and female patients were compared.Results The frequency was 42.11％ for AG genotype and 12.14％ for GG genotype of OPRM1 (118A＞G).For CYP3A4 * 1G,the frequencies of CC,TT,TC and CT were 29.69％,4.17％,65.67％ and 0.47％,respectively.For ABCB1,the frequencies of CC,TT,TC and CT were 13.07％,44.60％,0.28％ and 42.05％,respectivsly.For SLCO1B1,AG genotype appeared in 37.44 ％ of the patients,GG genotype appeared in 55.21％ of the patients.There was no difference between the male and the female patients.Conclusion Genotypes related to change of susceptibility to opioids including fentanyl and rocuronium were detected in high percentage of patients in North-western China,indicating that SNP assay for instruction of anesthetic practice be of value.
