Establishment and verification of fluctuation of reference intervals for biochemistry parameters in routine physical examina-tion
10.13602/j.cnki.jcls.2018.06.05
- VernacularTitle:常规体检生物化学项目波动性参考区间的建立与验证
- Author:
Bo YUE
1
;
Manjiao LIU
;
Dahai TANG
;
Jialei HE
;
Mengjie JIANG
;
Xiaoqiang WEI
;
Danjie LI
;
Shangzhen ZHANG
Author Information
1. 上海长海医院虹口院区检验科
- Keywords:
physical examination;
biochemistry parameter;
fluctuatio;
reference interval
- From:
Chinese Journal of Clinical Laboratory Science
2018;36(6):418-421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish and verify the fluctuation of reference intervals for biochestry parameters in routine physical exami-nation. Methods The results of biochemistry parameters,i.e., total protein (TP), albumin (Alb), total bilirubin (T-Bil), alanine aminotransferase (ALT), glucose (Glu), urea (Urea), creatinine (Cr), uric acid (UA), triacylglycerol (TG) and total cholesterol ( TC) from 2 089 healthy subjects in routine physical examination during consecutive 2014, 2015 and 2016 were randomly collected, in which all the results were within the reference range. The ratio (λ1) of the results of 2015 to those of 2014, and ratio (λ2) of the re-sults of 2016 to those of 2015 were calculated. λ1was analyzed statistically to establish the fluctuation of reference interval (CIλ). CIλ was verified by λ2.The personalized reference interval (CIp) was established by multiplying each result of 2015 and the upper and low-er limits of CIλ. The CIpwas verified by the results of 2016. The ratios of CIpto the upper and lower limits of conventional reference in-terval were calculated. Results The values of CIλwere as follows: TP: 0.91 to 1.08, Alb: 0.91 to 1.08, T-Bil: 0.58 to 1.74, ALT:0.49 to 1.99, Glu: 0.84 to 1.20, Urea: 0.67 to 1.50, Cr: 0.82 to 1.22, UA: 0.77 to 1.32, TG: 0.51 to 1.98 and TC: 0.80 to 1.26. Compared with conventional reference interval, the ratio of the upper and lower limits of CIp was lessened. Conclusion The personal-ized reference interval (CIp) which may increase the sensitivity of conventional reference intervals was established and verified.
