Expression of IL-33 in patients with systemic sclerosis and its correlation with TGF-β
10.13602/j.cnki.jcls.2018.04.07
- VernacularTitle:系统性硬化症患者血清IL-33的表达及与TGF-β的相关性
- Author:
Bintao SU
1
;
Lan ZHAO
;
Xingfei WU
;
Xin CHEN
;
Zunyi CHEN
;
Botao YIN
Author Information
1. 武汉市第一医院检验科
- Keywords:
systemic sclerosis;
interleukin-33;
growth stimulation expressed gene 2;
transforming growth factor
- From:
Chinese Journal of Clinical Laboratory Science
2018;36(4):267-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of interleukin-33 (IL-33),soluble growth stimulation expressed gene 2 (sST2) and transforming growth factor β1 (TGF-β1) in the patients with systemic sclerosis (SSc) and their correlations.Methods Serum IL-33,sST2 and TGF-β1 levels from 25 SSc patients and 25 healthy controls were determined by an enzyme linked immunosorbent assay (ELISA).The expressions of IL-33 in the damaged skin tissue of SSc patients and normal skin tissue were detected with the immunohistochemical staining.Results Serum IL-33 and TGF-β1 levels in SSc patients were significantly higher than that in healthy controls (P ＜ 0.05),and serum IL-33 levels were positively correlated with TGF-β1 levels in SSc patients (P ＜ 0.05).Immunohistochemical staining results showed that the expression level of IL-33 in the damaged skin tissue of SSc patients were significantly higher than that in normal skin tissue (P ＜ 0.05).However,there was no significant difference in the expression level of sST2 between SSc patinets and healthy controls.Conclusion Serum IL-33 levels in SSc patients increase significantly,which is correlated with the expression of TGF-β1,indicating that IL-33 may play an important role in the process of inflammation and fibrosis of SSc via the regulation of TGF-β1.
