Acute eosinophilic leukemia transformed from myelodysplastic syndrome: a case report and literature review
10.13602/j.cnki.jcls.2018.03.21
- VernacularTitle:骨髓增生异常综合征转为急性嗜酸粒细胞白血病1例并文献复习
- Author:
Jinlong MA
1
;
Bao'an CHEN
;
Zheng GE
;
Jiahua DING
;
Chong GAO
Author Information
1. 东南大学附属中大医院血液科
- Keywords:
myelodysplastic syndrome;
acute eosinophilic leukemia;
prognosis
- From:
Chinese Journal of Clinical Laboratory Science
2018;36(3):235-238
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize and explore the morphological characteristics,genetic alterations,immunophenotype and characteristics of molecular marker of acute eosinophilic leukemia (AEL),and improve the awareness for AEL.Methods A case of refractory hematopoietic dysplasia (MDS-RCMD) transformed to AEL in our hospital was retrospectively reviewed.Results The MDS-RC-MD patient transformed to AEL in 12 months after diagnosis.In his special bone marrow 10.4％ was blasts,while 70.8％ of bone marrow cells were eosinophils including 69.3％ of promyelocyte,myelocyte and metamyelocyte.Eosinophils accounted for 13.5％ in his peripheral blood.The blasts in bone marrow expressed CD34,CD117,HLA-DR,CD33,CD38 and CD13,and accompanied by complex chromosomal abnormalities.FI1L1/PDGFRα and ETV6/PDGFRβ fusion gene were negative.The patient died two months later following treating with AML regimen.Conclusion The AEL patient with negative FI1L1/PDGFRα and ETV6/PDGFRβ gene rearrangement,imatinib treatment is ineffectual.
