Expression of miR-206 in serum and placental tissue of patients with gestational hypertension and its clinical significance
10.13602/j.cnki.jcls.2018.02.07
- VernacularTitle:妊娠期高血压患者血清和胎盘组织miR-206的表达及意义
- Author:
Qifang LIU
1
Author Information
1. 中国医科大学附属盛京医院妇产科
- Keywords:
gestational hypertension;
serum;
placental tissue;
miR-206;
gestational eclampsia
- From:
Chinese Journal of Clinical Laboratory Science
2018;36(2):106-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of miR-206 in serum and placenta tissues of patients with gestational hypertension and its clinical significance.Methods The expression levels of miR-206 in serum and placental tissue samples from 34 pregnant women with gestational hypertension,26 with mild preeclampsia,27 with severe preeclampsia and 32 normal pregnant women were detected by quantitative real-time PCR (qRT-PCR),and their clinical pathological data were collected for correlation analysis.Results Compared with normal pregnant women,the expression levels of miR-206 in sera and placental tissues of pregnant women with gesta tional hypertension,mild preeclampsia or severe preeclampsia decreased significantly in turn (all P ＜ 0.05),and there was significant difference (F =79.10 and 129.18,respectively,both of P ＜ 0.05).The correlation analysis showed that the expression levels of miR-206 in sera of normal pregnant women and pregnant women with gestational hypertension,mild preeclampsia or severe preeclampsia were positively related to that in placental tissues (r =0.402,0.512,0.416 and 0.397,respectively,all P ＜ 0.05).In addition,the expression levels of miR-206 in serum and placental tissue of pregnant women with gestational hypertension were negatively related to systolic blood pressure,diastolic blood pressure and urinary protein level (P ＜ 0.05),but positively to gestational age,albumin level and neonatal body weight (P ＜ 0.05).Conclusion The expression of miR-206 in serum and placental tissue of pregnant women with gestational hypertension decreases significantly,which may be involved in the development and progression of gestational hypertension.
