The association between the intestinal microbiota -lipopolysaccharide -Toll -like receptor 4 axis and hepatocellularcarcinoma
10.3969/j.issn.1001-5256.2018.06.041
- VernacularTitle:肠道菌群-脂多糖-Toll样受体4轴与肝细胞癌的关系
- Author:
Rong HUANG
1
;
Jiajia NI
;
Yi GAO
Author Information
1. 南方医科大学珠江医院肝胆二科
- Keywords:
carcinoma;
hepatocellular;
enterobacteriaceae;
lipopolysaccharides;
Toll-like receptor 4;
review
- From:
Journal of Clinical Hepatology
2018;34(6):1325-1328
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is the major complication of various end -stage chronic liver diseases.Studies have shown that intestinal barrier injury and intestinal flora disturbance are commonly seen in patients with liver diseases , which may cause intestinal bacterial translocation and endotoxemia.Toll -like receptor 4 (TLR4) is a pattern recognition receptor in the liver and can bind to lipopolysaccharide (LPS), the active ingredient of endotoxin, result in immune inflammatory response via various signal transduction pathways , and finally promote hepatic fibrosis and tumorigenesis.This article reviews the intestinal microbiota -LPS -TLR4 axis and the pathogenesis of hepatocellu - lar carcinoma.
