The mechanism of chenodeoxycholic acid and its derivatives in hepatobiliary tumor

VernacularTitle:鹅脱氧胆酸及其衍生物在肝胆肿瘤中的作用机制
Author: Fei QI ¹ ; Yingmei TANG
Author Information

1. 昆明医科大学第二附属医院消化内科
Keywords: liver neoplasms; biliary tract neoplasms; chenodeoxycholic acid; review
From: Journal of Clinical Hepatology 2018;34(5):1115-1118
CountryChina
Language:Chinese
Abstract: Chenodeoxycholic acid (CDCA) is a primary bile acid and is involved in the digestion,transportation,and absorption of nutriments in the hepatobiliary system.Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily.In vivo and in vitro studies have demonstrated that CDCA is the natural ligand for FXR and involved in many cell signaling pathways,and it can inhibit the proliferation and induce the apoptosis of hepatobiliary tumor cells.This article reviews the association between CDCA and hepatobiliary tumor.