Role of silent information regulator 1 in development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2018.03.047
- VernacularTitle:沉默调节蛋白1在非酒精性脂肪性肝病发生发展中的作用
- Author:
Shuai YANG
1
Author Information
1. 桂林医学院
- Keywords:
non - alcoholic fatty liver disease;
silent information regulator transcription 1;
insulin resistance;
endoplasmic reticulum stress;
review
- From:
Journal of Clinical Hepatology
2018;34(3):649-652
- CountryChina
- Language:Chinese
-
Abstract:
Silent information regulator 1(SIRT1),a member of the Sirtuin family,is a deacetylase depending on nicotinamide adenine di-nucleotide and is mainly involved in energy metabolism,cell survival,aging,and apoptosis. Nonalcoholic fatty liver disease(NAFLD)is a chronic liver disease closely related to insulin resistance,oxidative stress,and lipid peroxidation. This article elaborates on the association of SIRT1 with energy metabolism,oxidative stress,lipid peroxidation,and endoplasmic reticulum stress and points out that SIRT1 is closely as-sociated with the development and progression of NAFLD.
