Influence of different types of cell senescence on the development and progression of liver fibrosis
10.3969/j.issn.1001-5256.2018.03.042
- VernacularTitle:肝脏不同类型细胞衰老对肝纤维化发生发展的影响
- Author:
Shan GUO
1
;
Xuefeng YANG
Author Information
1. 南华大学附属南华医院
- Keywords:
liver cirrhosis;
cell aging;
review
- From:
Journal of Clinical Hepatology
2018;34(3):627-630
- CountryChina
- Language:Chinese
-
Abstract:
Cell senescence is a basic cell response triggered by various stimuli and is a basic characteristic of living organism. Liver fibrosis refers to the pathological process of diffuse excessive deposition of extracellular matrix in the liver caused by abnormal proliferation of connec-tive tissue due to various pathogenic factors and can progress to liver cirrhosis and liver cancer. Studies have shown that cell senescence is closely associated with the progression of liver fibrosis. This article reviews the regulatory effect of different types of cell senescence on liver fibrosis.
