Clinical features and diagnosis and treatment of acute fatty liver of pregnancy:a report of 12 cases
10.3969/j.issn.1001-5256.2018.03.022
- VernacularTitle:妊娠期急性脂肪肝12例临床分析
- Author:
Kedi CHEN
1
;
Daofeng YANG
;
Guang CHEN
Author Information
1. 襄阳市中医医院肝胆科
- Keywords:
fatty liver;
pregnancy complications;
early diagnosis;
treatment
- From:
Journal of Clinical Hepatology
2018;34(3):558-561
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features and diagnosis and treatment of acute fatty liver of pregnancy(AFLP). Methods A retrospective analysis was performed for the clinical data of 12 patients with AFLP who were diagnosed and treated in Department of Infec-tious Diseases,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,from April 2012 to March 2017, including general data,clinical manifestations,laboratory markers,imaging examinations,treatment,and prognosis. Results All 12 pa-tients developed AFLP in late pregnancy,and major clinical manifestations included gastrointestinal symptoms,liver failure,jaundice,and coagulation disorder. All patients were given multimodality therapy to protect the liver,improve coagulation,and reduce infection;11 pa-tients underwent cesarean section;6 underwent blood filtration;5 underwent plasma exchange. One patient died,resulting in a mortality rate of 8.3%;5 perinatal infants died,resulting in a mortality rate of 35.7%. Conclusion In patients with AFLP,early diagnosis,timely ter-mination of pregnancy,maximum symptomatic/supportive treatment,and control of infection,as well as the artificial liver support system,is the key to improving the prognosis of mothers and infants.
