Change in immune status after antiviral therapy in patients with hepatitis C virus infection
10.3969/j.issn.1001-5256.2018.02.041
- VernacularTitle:HCV感染者抗病毒治疗前后免疫状态的变化
- Author:
Yingying JIANG
1
;
Xiaohui ZHANG
;
Sujun ZHENG
Author Information
1. 首都医科大学附属北京佑安医院疑难肝病及人工肝中心
- Keywords:
antiviral agents;
hepatitis C;
immunity;
review
- From:
Journal of Clinical Hepatology
2018;34(2):403-406
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis C virus (HCV) infection is a global public health issue.At present,pegylated interferon (IFN) combined with ribavirin is the major therapeutic regimen for anti-HCV treatment in China,but this regimen cannot achieve ideal sustained virologic response.Direct-acting antivirals (DAA) have achieved marked clinical effects in the treatment of patients with hepatitis C.This article briefly describes the change in immune status after anti-HCV treatment from the three aspects of innate immunity,adaptive immunity,and cytokines/ chemokines.The analysis shows that HCV patients have complex immunoregulation,and the results vary from one study to another.In general,the expression of NK cell surface receptor and its function tend to recover and may even recover to a normal state.IFN treatment cannot restore the function of virus-specific CD8 + T lymphocytes,while the change in cytotoxic T lymphocytes after DAA treatment has not been clarified.Further studies are needed to elucidate the long-term effect of DAA on cvtokines and chemokines.
