The Clinical Effect of Administration of Magnesium Sulfate in Cardiac Surgery.
- Author:
Jung Heui BANG
1
;
Seong Min MOON
;
Si Ho KIM
;
Kwang Jo CHO
;
Pil Jo CHOI
;
Jong Su WOO
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dong A University, Korea. jswoo@daumnet.donga.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Heart surgery;
Cardiopulmonary bypass;
Magnesium
- MeSH:
Alanine Transaminase;
Aspartate Aminotransferases;
Bilirubin;
Blood Gas Analysis;
Blood Urea Nitrogen;
Cardioplegic Solutions;
Cardiopulmonary Bypass;
Creatine;
Creatine Kinase;
Creatinine;
Electrolytes;
Humans;
Incidence;
Interleukin-10;
Interleukin-6;
Lactic Acid;
Magnesium Sulfate*;
Magnesium*;
Postoperative Period;
Prothrombin Time;
Thoracic Surgery*;
Thromboplastin;
Troponin I;
Tumor Necrosis Factor-alpha
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2006;39(5):366-375
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Hypomagnesemia is a common complication after cardiac surgery with cardiopulmonary bypass. The purpose of this study was to assess the clinical beneficial effect of administration of magnesium sulfate in cardiac surgery. MATERIAL AND METHOD: Thirty five patients scheduled for elective cardiac surgery were randomly assigned to magnesium group (n=20) which received magnesium sulfate in priming solution (1 g) and cardioplegic solution (1 g) or control group (n=15) which did not receive it. Arterial blood samples were drawn for measuring Mg++ and electrolytes contents, blood gas analysis, CBC, total protein, albumin, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase(LDH), troponin-I (TNI), prothrombin time (PT) and activated pratial thromboplastin time level (aPTT). Venous blood samples were drawn before and after the operation for measuring activated clotting time level (ACT). RESULT: Mg++ levels in magensium group were higher than those of control group at intraoperative and postoperative periods (p<0.05). dysrhythmias were lower in magnesium group (8 cases out of 17 patients, 46.4%) than in control group (10 cases out of 10, 100%, p=0.050). CONCLUSION: These results showed that administration of low dose magnesium sulfate during cardiac surgery prevented hypomagnesemia and lowered incidence of dysrhythmia.
