Familial short stature caused by ACAN gene mutation:a familial case report
10.3969/j.issn.1000-3606.2018.06.015
- VernacularTitle:ACAN基因变异致家族性身材矮小一家系报告
- Author:
Ting ZENG
1
,
2
;
Linyan LIAO
;
Niu LI
;
Jian WANG
;
Ji PENG
;
Yi GUO
;
Honghui LI
Author Information
1. 柳州市妇幼保健院儿童保健科 广西柳州 545001
2. 柳州市儿童发育障碍疾病研究重点实验室 广西柳州 545001
- Keywords:
familial short stature;
ACAN gene;
high-throughput sequencing;
gene mutation
- From:
Journal of Clinical Pediatrics
2018;36(6):463-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical phenotype and genetic variation of familial short stature. Method The clinical data of a familial short stature pedigree in Guangxi Zhuang autonomous region were retrospectively analyzed. The disease-causing gene was identified using targeted high-throughput sequencing combined with Sanger sequencing in May 2017. The related literature were searched and the relationship between the clinical phenotype and genotype of the ACAN gene mutation were summarized. Results The two patients were brothers, one was 9-year and 10-month old boy and the other was 7-year-old boy. Both of them had short stature. Their parents were non-consanguineous marriage and both were 150 cm in height, with. Their uncle and grandpa are also short stature. Gene sequencing revealed a novel heterozygous variation c.6193delC (p.Gln2065Serfs*27) in exon 12 of ACAN gene in both brothers, which were inherited from their father. No report of this mutation was found by searching literature and databases. A total of 11 related articles in English were retrieved. Totally (including our study) 32 patients in 41 families were reported to have the pathogenic variants of ACAN gene, including 4 variants from Chinese children, but no such reports were found in Chinese literatures. The most common clinical manifestation is idiopathic short stature, which is mostly familial but could also be sporadic. Some children also suffered from osteoarthritis, disc herniation or degeneration. Most of the children had advanced bone age, but some of them were normal or even lagged. Treatment of postponing puberty by growth hormone combined with gonadotropin-releasing hormone analogues can effectively improve final height. Conclusion Heterozygous mutation of ACAN gene can cause short stature in children and has significant familial genetic characteristics, and the clinical characteristics have no relationship with genotypes.
