Value of Tau protein and resistin in early prediction of premature brain damage induced by intrauterine infection
10.3969/j.issn.1000-3606.2018.06.010
- VernacularTitle:Tau蛋白及抵抗素对宫内感染致早产儿脑损伤早期预测作用
- Author:
Yuanqing MIAO
1
;
Yan XU
;
Lin MIAO
;
Jun WANG
Author Information
1. 徐州医科大学附属医院新生儿科 江苏徐州 221002
- Keywords:
premature infant;
intrauterine infection;
brain injury;
Tau protein;
resistin
- From:
Journal of Clinical Pediatrics
2018;36(6):443-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of plasma Tau protein and resistin in early prediction of brain injury in premature infants caused by intrauterine infection. Method A total of 47 premature infants in NICU with early-onset sepsis were selected as infection group from January 2017 to October. According to the cranial MRI, the infection group was further divided into brain injury group (22 cases) and non-brain injury group (25 cases). In addition, 12 normal preterm infants were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect plasma Tau protein and resistin levels on the first, third and seventh day after birth in three groups. Results The Tau protein in the brain injury group increased significantly on the first day, and then gradually decreased, while it was higher than that in the non-brain injury group and the control group at all time points, and there were statistical differences (P<0.05). At different time points, there was no difference in the level of Tau protein between the non-brain injury group and the control group (P>0.05). The level of resistin in the brain injury group increased significantly on the first day until the third day, and significantly decreased in the seventh day, and it was higher than that in the non-brain injury group and the control group at all time points, and there were statistical differences (P<0.05). Resistin increased on the first day, then gradually decreased, and returned to normal on the seventh day in the non-brain injury group. Conclusion Detection of plasma Tau protein and resistin levels within 3 days after birth may be helpful for early prediction of brain damage in premature infants with intrauterine infection.
