Dent disease combined with renal failure:two case report and literature review
10.3969/j.issn.1000-3606.2018.06.004
- VernacularTitle:Dent病合并肾衰竭2例报告并文献复习
- Author:
Hongwen ZHANG
1
;
Baige SU
;
Fang WANG
;
Xiaoyu LIU
;
Huijie XIAO
;
Yong YAO
Author Information
1. 北京大学第一医院儿科 北京 100034
- Keywords:
Dent disease;
renal failure;
acute tubulointerstitial nephritis;
child
- From:
Journal of Clinical Pediatrics
2018;36(6):416-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the etiology and prognosis of Dent disease combined with renal failure in children. Methods The clinical data of 2 children with Dent disease combined with renal failure from January 2014 to December 2016 were analyzed and the related literature was reviewed. Results Both of them were male, with the age of 8 and 10 years old respectively. Their renal functions were normal, and no renal calcification. Both of them had the history of upper respiratory tract virus infections within 1 week before the onset of renal failure. In case 1, acute phase (10 days) renal biopsy showed combined with acute tubulointerstitial nephritis, and his renal function recovered completely after glucocorticoids treatment. In case 2, renal biopsy at 6 months in course of disease showed the combined with subacute tubulointerstitial nephritis, and his renal function was improved partly after glucocorticoids treatment. Conclusions For children with Dent disease combined with acute renal failure, especially with upper respiratory tract virus infections and other inducement, renal biopsy should be early performed to exclude the possibility of acute tubulointerstitial nephritis, so that the treatment can be timely conducted and the prognosis can be improved.
