Comparison of two kinds of induction therapy in childhood acute myeloid leukemia
10.3969/j.issn.1000-3606.2018.05.001
- VernacularTitle:两种诱导治疗方案治疗儿童急性髓系白血病效果观察
- Author:
Qin ZHAI
1
;
Yi WANG
;
Hailong HE
;
Jun LU
;
Peifang XIAO
;
Fei DING
;
Hui LYU
;
Yina SUN
;
Junjie FAN
;
Shaoyan HU
Author Information
1. 南京医科大学附属苏州医院 苏州科技城医院
- Keywords:
acute myeloid leukemia;
induction chemotherapy;
curative effect;
adverse effect;
child
- From:
Journal of Clinical Pediatrics
2018;36(5):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of induction therapy in 3+7 protocol and 3+10 protocol in children with acute myeloid leukemia (AML). Methods Two protocols were carried out in our hospital during January 2010 to January 2015, namely 3+7 protocol(AML-06,A group) and 3+10 protocol (modified AML protocol, B group). A total of 56 cases aged from 1 year-old to 13 year-old were enrolled in A group with male to female ratio at 31:25. Five of them were classified as FAB M1, 25 as M2, 11 as M4, 10 as M5, 2 as M6 and 3 as M7. Another 44 cases aged from 1 year to 12 years were enrolled in B group with a male to female ratio at 26:18, and 17 cases were classified as FAB M2, 14 as M4, 9 as M5, 2 as M6, and 2 as M7. Efficacy and adverse events were compared between the two groups. Results The complete remission rate (CR) of B group was 70.4%, while CR in A group was 48.2%. Considering the CR, 3+10 protocol showed higher efficacy than 3+7 protocol (P< 0.05). The major adverse event was bone marrow suppression. Treatment-related mortality (TRD) in A group was 1.8%, which was lower than that in B group (2.3%). The overall survival rate in A group was 75.0%, which was lower than that in B group (86.4%, P< 0.05). Conclusions The induction therapy of 3+10 protocol and 3+7 protocol showed effectiveness for AML treatment. The 3+10 protocol showed a higher CR than 3+7 protocol with no TRD increase, indicating that the 3+10 protocol should be recommended for AML treatment in children.
