Diagnosis and treatment of atypical severe combined immunodeficiency disease in 7 children
10.3969/j.issn.1000-3606.2018.03.011
- VernacularTitle:不典型严重联合免疫缺陷病7例诊治分析
- Author:
Jianxin HE
1
;
Lanqin CHEN
;
Yuhong ZHAO
;
Xinlei JIA
;
Gang LIU
;
Baoping XU
;
Xiuyun LIU
;
Jingang GUI
;
Kunling SHEN
;
Zaifang JIANG
Author Information
1. 首都医科大学附属北京儿童医院
- Keywords:
severe combined immunodeficiency disease;
gene;
child
- From:
Journal of Clinical Pediatrics
2018;36(3):202-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnosis and treatment of atypical severe combined immunodeficiency disease (SCID). Methods The clinical data of atypical SCID in 7 children with IL2RG,JAK3,and RAG1 mutations were reviewed and analyzed from September 2012 to June 2017. Results In 7 cases (6 males and 1 female), there were 5 infants, 1 toddler and 1 school-age child. Cases 2, 4, and 6 were classic SCID clinical phenotypes. Cases 1, 3, 5, 7 were atypical SCID clinical phenotypes. Case 6 were diagnosed with Omenn syndrome. Cases 2, 5 were classic SCID immune phenotypes, cases 1, 3, 4, 6, 7 were atypical SCID immune phenotypes, and case 1 had maternal chimera. The next generation sequencing indicated that case 1 had a compound heterozygous JAK3 mutation with c.3097-1G>A/c.946-950GCGGA>ACinsGGT.Cases 2,3,and 4 had IL2RG mutations,with c.865C>T/p.R289X,c.664C>T/R222C,52delG,respectively.Case 5 had JAK3 mutations with c.2150A>G/p.E717G and c.1915-2A>G.Sanger sequencing indicated that case 6 had a RAG1 mutation of complex heterozygosity with c.994C>T/p.R332X and c.1439G>A/p.S480N. Case 7 had homozygous RAG1 mutation with c.2095C>T/p.R699W.Conclusion Under certain conditions,gene mutation can lead to atypical clinical and/or immune phenotypic SCID.
