Congenital nephrotic syndrome with neonatal polycythemia: a case report

VernacularTitle:先天性肾病综合征合并新生儿红细胞增多症1例报告
Author: Zonglai HAN ¹ ; Lei YANG ; Yi LIN ; Yongwei LI ; Chaoying YAN
Author Information

1. 吉林大学第一医院儿科
Keywords: neonate; polycythemia; congenital nephrotic syndrome
From: Journal of Clinical Pediatrics 2018;36(3):175-177
CountryChina
Language:Chinese
Abstract: Objectives To investigate the relationship between congenital nephrotic syndrome (CNS) and neonatal polycythemia, and clinical diagnosis and treatment. Methods The clinical manifestations, diagnosis, and treatment of a case of CNS with neonatal polycythemia were retrospective analyzed, and the related literature were reviewed. Results A male infant had abdominal distention after his birth, followed by feeding intolerance and poor response. On the third day of birth, he was diagnosed of neonatal polycythemia according to the levels of hemoglobin (249 g/L) and hematocrit (0.714 L/L). And after a partial exchange transfusion, the symptoms were improved. On the sixth day of birth, the infant had edema, urinary protein +++, serum albumin at 12.7 g/L and blood cholesterol at 8.84 mmol/L, and was clinical diagnosed of CNS. Oral hormone therapy was ineffective and he died 32 days after birth. Conclusions CNS combined with neonatal erythrocytosis is rare in clinic. The co-existing of the two is more likely to induce thromboembolism and organ dysfunction, and the clinical prognosis is poor.