Acute myelitis with positive GM1 antibodies in children: a report of two cases
10.3969/j.issn.1000-3606.2018.02.010
- VernacularTitle:单唾液酸神经节苷脂抗体阳性的急性脊髓炎2例报告
- Author:
Di QIE
1
;
Xiaotang CAI
Author Information
1. 四川大学华西第二医院儿科 四川大学出生缺陷与相关妇儿疾病教育部重点实验室 四川成都 610041
- Keywords:
acute myelitis;
GM1 antibodies;
Helicobacter pylori
- From:
Journal of Clinical Pediatrics
2018;36(2):131-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical characteristics and treatment of acute myelitis in children. Methods Clinical data and prognosis of two cases of pediatric acute myelitis with positive serum monosialoganglioside (GM1) antibodies were analyzed, and related literatures were reviewed. Results Two cases had clinical symptoms and MRI change of myelitis with positive serum GM1-IgM antibody and thyroid antibody. Two cases had positive serum Helicobacter pylori IgG antibody and one case has positive Mycoplasma pneumoniae IgM antibody.After treated with high doses of glucocorticoid and gamma-globulin, two cases were discharged as symptoms improved. After discharged, treatment with oral prednisone and rehabilitation were continued. One case recovered completely while another could stand alone by supporting after 3 months follow-up. Conclusion Immunologic injury played an important role in pathogenesis of acute pediatric myelitis with serum positive GM1 antibodies, which had better treatment outcome and prognosis. This type of myelitis may have intestinal Helicobacter pylori infection.
