Neonatal inflammatory bowel disease: a report of 2 cases with literature review
10.3969/j.issn.1000-3606.2018.02.008
- VernacularTitle:新生儿炎症性肠病2例报告及文献复习
- Author:
Zhaohui LI
1
;
Wenqing KANG
;
Yaodong ZHANG
;
Bangli XU
;
Dapeng LIU
Author Information
1. 郑州大学附属儿童医院 河南省儿童医院 郑州儿童医院 河南郑州 450018
- Keywords:
inflammatory bowel disease;
infants;
newborn
- From:
Journal of Clinical Pediatrics
2018;36(2):121-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of neonatal inflammatory bowel disease (IBD). Methods The clinical data of two neonates diagnosed with IBD. Clinical manifestation, laboratory examination, imaging, endoscopy and histopathological findings, treatment plan and prognosis were included. Results The clinical manifestations were fever, diarrhea, oral ulcer in two cases of neonatal IBD in this study. Laboratory findings showed inflammatory indicators (such as white blood cells, C-reactive protein) increased mainly accompanied by decreased hemoglobin, platelet, plasma albumin and other indicators. Endoscopic and pathological manifestations were significantly different in ulcerative colitis (UC) and Crohn disease (CD) children. The lesions range of UC patients were mainly sigmoid colon, and CD patients ileocecal. Conclusions For neonates with highly suspected IBD, positive endoscopy and gene detection are recommended. Early diagnosis and standard treatment are important. For children with refractory IBD with IL-10 and IL-10 receptor gene mutations, hematopoietic stem cell transplantation is feasible and could improve its prognosis.
