A matched case-control study on perinatal risk factors of early onset thrombocytopenia in full-term small for gestational age infants
10.3969/j.issn.1000-3606.2018.01.009
- VernacularTitle:足月小样儿早发型血小板减少症围生期危险因素配对对照研究
- Author:
Yajun JIANG
1
;
Shi CHEN
;
Xueqiu WANG
;
Luquan LI
Author Information
1. 重庆医科大学附属儿童医院新生儿诊治中心 儿童发育疾病研究教育部重点实验室 儿童发育重大疾病国家国际科技合作基地 儿科学重庆市重点实验室 国家住院医师规范化培训示范基地 重庆 400014
- Keywords:
small for gestational age infant;
early-onset thrombocytopenia;
intrauterine distress;
early-onset sepsis;
risk factor
- From:
Journal of Clinical Pediatrics
2018;36(1):40-43,60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the perinatal risk factors of early onset thrombocytopenia (EOT) in full-term small for gestational age infants. Methods A 1:1 or 1:2 matched case control study was carried out. A total of 93 full-term small for gestational age infants with EOT were selected from April 2008 to July 2014 as the case group, and the non EOT full-term small for gestational age infants with the birth weight difference <250 g and the gestational age difference <3 days were selected as the control group. The clinical data during perinatal period and laboratory examination results after admission were collected retrospectively. And the differences between the two groups were compared. Results The incidence of intrauterine distress (41.9％ vs. 25.8％, χ2=7.35, P=0.007), amniotic fluid contamination (39.8％ vs. 27％, χ2=4.66, P=0.031), and early-onset sepsis (39.8％ vs. 27％, χ2=4.66, P=0.031) were significantly higher in the case group than those in the control group. Conditional logistics regression analysis showed that intrauterine distress (β=0.60, OR=1.82, 95％CI=1.04～3.17, P=0.035) and early-onset sepsis (β=1.69, OR=5.44, 95％CI=1.11～26.76, P=0.037) were related to EOT. Conclusions Intrauterine distress and early-onset sepsis are risk factors for the onset of EOT in full-term small for gestational age infants.
