Association of STAT3 gene polymorphism with susceptibility to Henoch-Sch?nlein purpura
10.3969/j.issn.1000-3606.2018.01.003
- VernacularTitle:STAT3基因多态性与过敏性紫癜易感性的相关性研究
- Author:
Fangfang ZHONG
1
;
Yuan ZHUANG
;
Xiaoyan MAO
;
Taiguang ZHOU
;
Hongying CHEN
;
Xiao HU
;
Yan ZOU
;
Chunyan LIU
;
Hong YANG
;
Wenjun LIU
Author Information
1. 西南医科大学附属医院儿一科 四川泸州 646000
- Keywords:
signal transducer and activator of transcription -3;
single nucleotide polymorphism;
child
- From:
Journal of Clinical Pediatrics
2018;36(1):9-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of two loci (rs2293152, rs9579700) gene polymorphisms of signal transduction and transcription factor-3 (STAT3) with susceptibility to Henoch-Scho. .nlein purpura (HSP) and HSP nephritis (HSPN). Methods From September 2013 to September 2015, 180 children with HSP (group HSP) and 205 healthy children (control group) were enrolled in this study. Single nucleotide polymorphism (SNP) of intron 11 rs2293152C/G and intron 23 rs957970C/T of STAT3 gene was detected by sequence specific primer polymerase chain reaction (SSP-PCR). Results The frequency of CC genotype in STAT3 gene intron 11 rs2293152 in HSP group (26.1％) was significantly higher than that in control group (8.8％), and the frequency of allele gene of rs2293152C in HSP group (48.6％) was significantly higher than that in control group (32.7％) (P=0.013, 0.025). There were no differences in distribution of genotype and allele in rs957970C/T loci of intron 23 of STAT3 gene between two groups (P>0.05). The frequencies of genotype and allele of the two loci of STAT3 gene were no difference between HSPN and non HSPN groups (P>0.05). Conclusions The allele gene C of intron 11 rs2293152C/G of STAT3 gene may be a susceptible gene of HSP, while there was no association of 23 rs957970C/T polymorphism to HSP and there was no association of the two loci polymorphisms to HSPN.
