Analysis of the risk factors of intravenous immunoglobin-resistant Kawasaki diseases
10.3969/j.issn.1000-3606.2018.01.001
- VernacularTitle:丙种球蛋白非敏感型川崎病危险因素分析
- Author:
Ziming WU
1
;
Zhengyu ZHANG
;
Zhaoyang LUO
;
Qinlin SHI
;
Wenlong ZHAO
Author Information
1. 重庆医科大学医学信息学院卫生决策与医疗大数据教研室 重庆 400016
- Keywords:
Kawasaki disease;
intravenous immunoglobulin-resistant;
risk index
- From:
Journal of Clinical Pediatrics
2018;36(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the early laboratory indicators for risk of intravenous immunoglobin-resistant Kawasaki diseases. Methods The clinical data were retrospectively analyzed in 881 Kawasaki disease patients (group A: 26 cases of intravenous immunoglobin-resistant; group B: 855 cases of intravenous immunoglobin-sensitive) from July 1, 2015 to June 30, 2016. After 1:3 matching with age and sex, the regression model for each of variables including sex, age, fever days, temperature, red blood cell count (RBC), white blood cell count (WBC), neutrophil (N), lymphocyte (L), platelet count (PLT) and C reactive protein (CRP), was constructed by conditional logistic regression analysis. Results Compared with group B, group A had significantly lower RBC count and higher PLT (P<0.05). Logistic regression analysis showed that, with the age, the regression model was Y=-2.87+0.01×PLT (PLT OR=1.01, 95％ CI: 1.00～1.01, P<0.01); with the sex, Y=-32.98+0.44×WBC+0.28× N+0.01×PLT (WBC OR=1.55, 95％ CI: 1.17～2.05, P<0.01; N％ OR=1.32, 95％ CI: 1.04～1.68, P<0.05; PLT OR=1.01, 95％ CI 1.00～1.01, P<0.01). Conclusion In case that abnormally high levels of PLT exist in confirmed Kawasaki disease, it should be aware of possibility of the intravenous immunoglobin-resistant Kawasaki disease.
