The Function of 5-HT(1A) Receptor and Pharmacotherapy.
- Author:
Won KIM
1
;
Won Myong BAHK
Author Information
1. Department of Psychiatry, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
5-HT(1A) receptor;
Serotonin;
Depression;
Anxiety;
Schizophrenia;
Psychopharmacology
- MeSH:
Alzheimer Disease;
Antipsychotic Agents;
Anxiety;
Autoreceptors;
Brain;
Depression;
Drug Therapy*;
Felodipine;
Hippocampus;
Neurogenesis;
Prefrontal Cortex;
Psychopharmacology;
Receptor, Serotonin, 5-HT1A*;
Schizophrenia;
Serotonin;
Serotonin Uptake Inhibitors;
Stroke
- From:Korean Journal of Psychopharmacology
2006;17(3):253-262
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
5-HT(1A) receptor is implicated in the pathogenesis and the therapeutic mechanism of various psychiatric disorders. Especially, the mechanism of action of selective serotonin reuptake inhibitors (SSRIs) was hypothesized that 5-HT(1A) autoreceptor desensitization plays an important role in the treatment of depression and anxiety. 5-HT(1A) receptor stimulation may also mediate the neurogenesis of prefrontal cortex and hippocampus. The 5-HT(1A) agonism has an important meaning in the treatment of schizophrenia. Most atyptical antipsychotics have the property of 5-HT(2A) antagonist, and some have that of 5-HT(1A) agonist. In the various regions of brain, 5-HT(1A) and 5-HT(2A) have the functionally antagonistic properties. Recently, 5-HT(1A) receptor-related agents have been investigated in the treatment of acute ischemic stroke and Alzheimer's disease. Therefore, the further understanding about the 5-HT(1A) receptors in the brain functions will provide the development of future drugs and the advancement of psychopharmacology.
