The Expression of LRG1 in Cervical Squamous Carcinoma and Its Relationship with Microvessel Density
10.3969/j.issn.1003-4706.2018.06.010
- VernacularTitle:LRG1在宫颈鳞癌组织中的表达及其与微血管密度的关系
- Author:
Rui TIAN
1
;
Zhen－ling DUAN
;
Jing MA
Author Information
1. 昆明医科大学第一附属医院妇科
- Keywords:
LRG1;
CD105;
MVD;
Cervical squamouscarcinoma
- From:
Journal of Kunming Medical University
2018;39(6):44-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of LRG1 (Leucine－rich alpha－2－glycoprotein 1) and CD105 (Endoglin) in normal cervical tissues , cervical intraepithelial neoplasia (CIN)Ⅱ－ Ⅲ and cervical carcinoma. Furthermore, to explore the function of LRG1 in cervical carcinoma pathogenesis and the relationship between LRG1 and microvessel density.Methods The expression levels of LRG1 and CD105 were detected by immunohistochemistry in 40 cervical carcinoma tissues, 20 CINⅡ－ Ⅲ tissues and 20 normal cervical tissues. Results Compared to the normal cervix, the expression of LRG1 in CINⅡ－ Ⅲ and cervical squamous cell carcinoma was significantly increased (P＜0.05).LRG1expression was correlated to clinical stage and lymph node metastasis (P＜0.05) . But there was no correlation between LRG1 expression and age, the size of tumor, pathologic grades and depth of invasion (P＞0.05).With the deepening of cervical lesions, CD105－MVD (X± s) increasedsignificantly (P＜0.05).The expression of CD105－MVD in cervical carcinomawas related to clinical stage, lymph node metastasis and the size of tumor. The difference was statistically significant (P＜0.05) . There was no correlation between CD105－MVD and age, pathologic grades and depth of invasion (P＞0.05).Positive correlation was found between the expression of LRG1 and CD105－MVD (r=0.944,P＜0.05).Conclusions The expression of LRG1 and CD105－MVD is up－regulated and shows a positive correlation, which suggests that the abnormal expression of LRG1 and CD105－MVD may involve in the occurrence and development of cervical squamous carcinoma.
