Pyrethroid Exposure and Related Factors among Pregnant Women in the First Trimester in Rural Yunnan Province, China
10.3969/j.issn.1003-4706.2018.06.009
- VernacularTitle:云南农村妇女孕早期拟除虫菊酯类农药暴露及影响因素
- Author:
Lin SUN
1
;
Xia XIAO
;
Yan LI
;
Si－wei YANG
;
Qing－hua XU
;
Rui MA
;
Jie WU
;
Chao ZHANG
;
Guang－ping GUO
Author Information
1. 昆明医科大学公共卫生学院
- Keywords:
First trimester;
Pyrethroid pesticides;
Exposure;
Rural area
- From:
Journal of Kunming Medical University
2018;39(6):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level and relevant factors of pyrethroid pesticide exposure among pregnant women during the first trimester in rural areas of Yunnan province,and to provide basic data for further study and provide a basis for the formulation of intervention measures to reduce exposure.Methods According to the birth cohort of rural Yunnan built in 2014, pregnant women in the first trimester were recruited in two townships of an agricultural county who were confirmed pregnant and continued pregnancy in antenatal clinics. The concentration of the metabolites of the pesticides in the urine of women was determined by super high performance liquid chromatography and the contact status of pyrethroid pesticides was analyzed using a questionnaire survey. Results A total of 419 women in the first trimester were surveyed and 94.51% of women detected at least one of the pyrethroid metabolites, among which the detection rates of 3－Phenoxybenzoic acid (3－PBA), cis－/trans－3－ (2, 2－Dichloroethenyl)－2, 2－dimethyl－cyclopropanecarboxylate (cis－/trans－DCCA) and 4－fluoro－3－phenoxybenzoic acid (4－F－3－PBA) were 79.47%, 62.05% and 24.58%,and the median concentrations were 3.53 ng/mL, 14.80 ng/m L and less than the minimum detection limit 0.4 ng/m L.Only 12 people (2.95%) reported that they had exposure to pesticides.Self－reported exposure rate was not consistent with the actual exposure rate.Multivariate linear regression analysis showed that the season was a factor affecting the level of three metabolites in women in the first trimester. Higher lever was found in women in spring (t=2.147,P=0.032), summer (t=2.144,P=0.035) and winter (t=2.453,P=0.015) compared to those in autumn.Conclusion Pyrethroid pesticides were widely exposed in the pregnant women in rural areas of Yunnan province. Some women have higher exposure level, which is related to the season.
