A Study on the Synthesis of Veratraldehyde

VernacularTitle:藜芦醛的合成
Author: Kai1) HU ¹ ; Jie1) DONG ; Xiang1) LI ; Dong1) LI ; Yu－xiang1) ZHAO ; Yan－ren1) ZHU ; Jing1) WANG ; Dan－dan2) LIU ; Lin－zong3) ZHOU ; Lei－lei4) LIANG ; Jing－bo CHEN
Author Information

1. 云南大学教育部自然资源药物化学重点实验室
Keywords: Veratraldehyde; Synthesis; Olefin isomerization; Ozonation/reduction
From: Journal of Kunming Medical University 2018;39(6):31-34
CountryChina
Language:Chinese
Abstract: Objective Veratraldehyde is an important pharmaceutical intermediate and chemical raw material. Taking common synthetic methods of Veratraldehyde into consideration, the study is aimed to further investigate a more efficient synthetic route in order to provide a solid foundation for the application of Veratraldehyde.Methods This article introduces an alternative method based on the Triton－B catalyzed olefin isomerization of methyl Eugenol followed by ozonation/reduction reaction.Results In the experiment,the optimal conditions was selected by investigating the influence of reaction time, reaction temperature and catalyst dosage on the yield of Veratraldehyde. The total yield of this 2－step reactions was 64% . Conclusion The above－mentioned synthesis method only requires raw materials that are easily acquired and its relative reaction conditions are mild, thus it will provide values in the industrial applications.