Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury

VernacularTitle:TDP-43与神经退行性疾病及脑损伤的相关性研究进展
Author: Bin CAI ¹ ; Hai SONG ; Zhen WANG ; Xue HAN
Author Information

1. 昆明医科大学法医学院
Keywords: TDP-43; Neurodegenerative disease; Forensic pathology; Brain injuries
From: Journal of Kunming Medical University 2018;39(5):124-127
CountryChina
Language:Chinese
Abstract: TAR DNA/RNA -binding domain protein 43 (TDP-43) is a highly conserved and widely expressed nuclear protein. TDP-43 is recognized as a pathological marker protein of amyotrophic lateral sclerosis (ALS),frontotemporal lobar degeneration (FTLD) and alzheimer disease (AD).This article discusses the structure and the function ofTDP-43 and the relationship of its expression in neurodegenerative disease.Meanwhile, this article emphatically probes into the specific expression andfunction of TDP-43 in acute and chronic brain injury based on the knowledge of its biological characteristics,aiming to explore the feasibility for determining the cause of death and the injury and disability situations by TDP-43 in forensic pathology.