Expression and Significance of Plasma miR-223-3p in Diabetic Kidney Diseaseat Different Stages
10.3969/j.issn.1003-4706.2018.05.010
- VernacularTitle:miR-223-3p在不同分期的糖尿病肾脏疾病血浆中的表达差异及意义
- Author:
Jun-Yi HE
1
;
Lan LI
;
Rong LI
;
Yun-Hua HUANG
;
Qiu-Ping YANG
;
Ya-Nan WU
;
Li-Hua ZHANG
Author Information
1. 昆明医科大学第一附属医院老年内分泌科
- Keywords:
Diabetic kidney disease;
miR-223-3p;
Target genes;
Quantitative real-time PCR
- From:
Journal of Kunming Medical University
2018;39(5):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of miR-223-3p in the plasma of patients with diabetic kidney disease and its clinical significance. Methods The expression levels of plasma miR-223-3p in normoalbuminuric group (DM) , microoalbuminuria group (Micro-DKD) , macroalbuminuria group (Macro-DKD) and healthy controls were measured by quantitative real-time polymerase chain reaction (qRT-PCR) . To analysis the relationship with clinical pathological parameters,target genes of miR-223-3p were predicted with bioinformatics software. Results The levels of miR-223-3p in the plasma of the remaining three groups were significantly lower than those in the healthy controls (P＜0.001), and the decrease was positively correlated with the severity of the disease. The potential target genes of miR-223-3p identified by bioinformatics softwares include IL6ST and PRKCE. Conclusion The expressionof miR-223-3pin diabetic kidney disease (DKD) patients' plasma decreased and was positively correlated with the severity of the disease. It may play an important role in the development and progression of diabetic kidney disease through its target genes.
