A Novel Derivative of Panax Notoginseng Sapogenin and Its Antitumor Activity
10.3969/j.issn.1003-4706.2018.05.004
- VernacularTitle:一个新颖的三七皂苷元衍生物及其抗肿瘤活性
- Author:
Rui LI
1
;
Wen-Yue DUAN
;
Cheng ZOU
;
Qing ZHAO
;
Li HUANG
;
Jin-Na ZHOU
;
Jian-Lin HU
;
Wei-Min YANG
Author Information
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室
- Keywords:
1',2'-isopropylidenedioxy-propanedioxy-propanedioxy;
Panax notoginseng saponins;
Smith degradation;
CDC25B
- From:
Journal of Kunming Medical University
2018;39(5):11-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the derivatives of panax notoginseng sapogenins and their anti-tumor activities. Methods The ginsenosides Rg1 was treated with Smith degradation. The products were separated and purified by silica gel column chromatography. The structures of the products were determined by NMR spectra. The activity of anti-tumor cells of compound (1) and 1'-hydroxyethanedioxy PT was detected with CDC25B activity assay and fluorescence technique. Results 1'-hydroxyethanedioxy PT , 20 (s)-protopanaxatriol (PT), and 24, 25 - en-3β, 6 α-dihydroxy-12, 20-(1', 2'-isopropylidenedioxy) propanedioxy-dammarane (1) were isolated and identified. Conclusion Compound (1), named 1',2'-isopropylidenedioxy-propanedioxy-pro-panedioxy , is a novel derivative of panax notoginseng sapogenin with better inhibitory activity against CDC25B.
