A Comparison of the Effect of Lidocaine or Sodium Bicarbonate Mixed with Rocuronium on Withdrawal Movement, Mean Arterial Pressure and Heart Rate during Rocuronium Injection.
10.4040/jkan.2009.39.2.270
- Author:
Sung Suk LEE
1
;
Haesang YOON
Author Information
1. Gil Medical Center, Gachon University of Medicine & Science, Incheon, Korea.
- Publication Type:Original Article ; English Abstract ; Randomized Controlled Trial
- Keywords:
Muscle relaxants;
Rocuronium;
Pain;
Injection
- MeSH:
Adult;
Androstanols/administration & dosage/*adverse effects;
Anesthetics, Local/administration & dosage/*therapeutic use;
Blood Pressure/*drug effects;
Female;
Heart Rate/*drug effects;
Humans;
Injections, Intravenous;
Lidocaine/administration & dosage/*therapeutic use;
Male;
Middle Aged;
Neuromuscular Nondepolarizing Agents/administration & dosage/*adverse effects;
Pain/*prevention & control;
Sodium Bicarbonate/*administration & dosage
- From:Journal of Korean Academy of Nursing
2009;39(2):270-278
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was performed to find out the effects of lidocaine or 8.4% sodium bicarbonate mixed with rocuronium on mean arterial pressure, heart rate and withdrawal movement. METHODS: Data collection was performed from December 15, 2006 through May 31, 2007. Seventy-five patients with American Society Anesthesiologist (ASA) physical status I & II, under general anesthesia, were randomly assigned to 1 of 3 groups: R group (RG) received rocuronium 0.6 mg/kg; RL group (RLG), rocuronium 0.6 mg/kg mixed with 2 mL of 2% lidocaine; RS group (RSG), rocuronium 0.6 mg/kg with the same volume of 8.4% sodium bicarbonate. Mean arterial pressure, heart rate and withdrawal movement were observed from its injection until 5 min after endotracheal intubation. RESULTS: The incidence of withdrawal movement with its corresponding injections was 72%, 40% and 4% in RG, RLG and RSG, respectively (p<.001). Score of withdrawal movement was the lowest in RSG of all groups (p<.001). While mean arterial pressure (p=.011) in RSG decreased significantly, and heart rate (p=.003) in RG increased more with its injection than before induction of anesthesia. CONCLUSION: Administration of the equivalent volume of 8.4% sodium bicarbonate with rocuronium is more effective than that of lidocaine with rocuronium compared with rocuronium only, in preventing withdrawal movement and in stabilizing mean arterial pressure and heart rate.
