Effects of Exchange Transfusion on Renal Function, Inflammatory Factors and Blood Internal Environment in Children with Hyperbilirubinemia
10.3969/j.issn.1003-4706.2018.01.022
- VernacularTitle:换血对高胆红素血症患儿肾功能、炎症因子及血液内环境的影响
- Author:
Jing-Lei QU
1
;
Yuan-Zheng YANG
Author Information
1. 河北省血液中心成分科
- Keywords:
Hyperbilirubinemia;
Exchange transfusion;
Renal function;
Inflammatory response;
Oxidative stress response
- From:
Journal of Kunming Medical University
2018;39(1):96-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of exchange transfusion on renal function, inflammatory factors and blood internal environment in children with hyperbilirubinemia. Methods Neonates with hyperbilirubinemia treated in neonatal intensive care unit of the hospital between February 2015 and March 2017 were selected as the research subjects and divided into two groups by random number table method. Combined group received exchange transfusion combined with blue ray irradiation, and control group received blue ray irradiation. The serum levels of bilirubin, renal function indexes, inflammatory response indexes and oxidative stress response indexes were measured 24 hours after the treatment. Results 24 hours after the treatment,serum TBIL,BUN,Cr,β2-MG, CysC, TRF, CRP, IL-6, TNF-α, MDA and AOPP levels of combined group were greatly lower than those of control group whereas SOD, CAT and GSH-Px contents were greatly higher than those of control group. Conclusion Exchange transfusion can improve the renal function and inhibit the inflammatory and oxidative stress response in children with hyperbilirubinemia.
