Comparison of the Curative Effect of Concurrent Chemoradiotherapy and Sequential Chemoradiotherapy in Non-small Cell Lung Cancer
10.3969/j.issn.1003-4706.2015.06.011
- VernacularTitle:同步放化疗与序贯化放疗治疗Ⅲ期不能手术非小细胞肺癌的临床疗效
- Author:
Hua BAI
1
;
Min-Quan HOU
;
Xiao-Ning BAI
Author Information
1. 陕西省富平县医院呼吸内科
- Keywords:
Non-small cell lung cancer;
Concurrent chemoradiotherapy;
Sequential chemoradiotherapy
- From:
Journal of Kunming Medical University
2015;36(6):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the curative effect and toxicity of concurrent chemoradiotherapy and sequential chemoradiotherapy in non-small cell lung cancer patients.Methods 64 patients with unresectable stage Ⅲ non-small cell lung cancer in our hospital between May 2010 and Mar 2013 were randomly assigned into concurrent group and sequential group for this test.Concurrent group patients (32 cases) were given Cisplatin and Gemcitabine on the 1,4,7 week during radiotherapy.Sequential group patients accepted 3 cycles chemotherapy before radiotherapy.Results The response rate was 68.8％ in concurrent group,and 43.8％ in sequential group.Difference was significant between the response rates of the two groups (P ＜ 0.05).There was significant difference in haematological toxicity,which was 100％ in concurrent group and 65.6％ in sequential group (P ＜ 0.05).There was no significant difference in rates of radiation pneumonia and radiation esophagitis in the two groups (P ＞ 0.05) Conclusions Concurrent chemoradiotherapy has better curative effect than sequential chemoradiotherapy.Concurrent chemoradiotherapy is a safe and effective treatment for patients with unresectable stage Ⅲ non-small cell lung cancer.
