Application of quinolones in children with severe infection
10.3760/cma.j.issn.1671-0282.2018.11.017
- VernacularTitle:喹诺酮类药物在儿童重症感染中的应用分析
- Author:
Mei YANG
1
;
Suyun QIAN
Author Information
1. 100045 北京,国家儿童医学中心,首都医科大学附属北京儿童医院药学部
- Keywords:
Quinolones;
Children;
Severe infections;
Off-label drug use;
Clinical pharmaceutics
- From:
Chinese Journal of Emergency Medicine
2018;27(11):1271-1275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the efficacy and safety of quinolones in children with severe infection. Methods Patients with severe infections treated in the Pediatric Intensive Care Unit of Beijing Children's Hospital from November 2016 to January 2018 were enrolled. The clinical data were collected and analyzed. Results Totally 24 children were treated with quinolones, including levofloxacin, ciprofloxacin and moxifloxacin. Patients with poor initial treatment were treated with levofloxacin or ciprofloxacin on the basis of drug sensitivity for bacterial infections. Moxifloxacin was used to treat Mycoplasma pneumoniae infection in patients poorly treated by macrolides antibiotics or macrolide-resistance gene positive. Among the 24 cases, 1 case (4.2 ％) was cured, 19 cases (79.1 ％) treated effectively, 1 case had no response (4.2 ％), and 3 cases (12.5 ％) discharged automatically during treatment, with a response rate of 83.3 ％. The consciousness, skin, joint and gastrointestinal function were closely observed; blood routine test, liver and kidney function were closely monitored. There were no adverse drug reactions during the period of medication. Conclusions Quinolones can improve efficacy and prognosis for pediatric patients with severe infections. There are no drug related adverse reactions, indicating a safe short-term use. The use of quinolones in children is super-instructive, and clinical pharmacists should assist physicians in doing related work and reduce medical risks.
