Analysis of risk factors of non HIV pneumocystis jirovecii pneumonia patients complicated with cytomegaloviremia
10.3760/cma.j.issn.1671-0282.2018.09.010
- VernacularTitle:非艾滋病耶氏肺孢子菌肺炎患者合并巨细胞病毒血症的危险因素分析
- Author:
Hui JIANG
1
;
Qiubin ZHANG
;
Huadong ZHU
Author Information
1. 北京协和医院急诊科
- Keywords:
Non-HIV patient;
Pneumocystis jirovecii;
Pneumonia;
Cytomegalovirus;
Cytomegaloviremia
- From:
Chinese Journal of Emergency Medicine
2018;27(9):1004-1009
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors and outcome of non HIV pneumocystis jirovecii pneumonia (non HIV-PJP) patients complicated with cytomegaloviremia. Methods A total of 101 non HIV-PJP patients treated in Beijing Union Medical College Hospital in 2014 were retrospective analyzed. The cytomegaloviremia was defined as plasma cytomegalovirus DNA (CMV-DNA) ≥ 500 copies/mL, and patients were divided into the cytomegaloviremia group and non cytomegaloviremia group. Demographics, clinical features, endoscopic appearance and treatment of patients in the two groups were analyzed. Chi-square test and other method of univariate statistical analysis were performed. Logistic regression analysis was used to analyze the independent risk factors for non-HIV-PJP combined cytomegaloviremia. Results Of the 93 non-HIV-PJP patients, the incidence of cytomegaloviremia were 44.1％. Univariate analysis showed that risk factors of PJP patients complicated with cytomegaloviremia were female, lymphocyte count, C-reactive protein (CRP), positive hexamine silver staining, positive pneumocystis jirovecii pneumonia DNA (PJP-DNA), and invasive mechanical ventilation. Multivariate logistic regression analysis showed that independent risk factors of PJP patients complicated with cytomegaloviremia were female (OR=4.222, 95％CI:1.453-12.271, P=0.008), coinfection of fungal (OR=10.113, 95％ (OR=10.113, 95％CI:1.38-74.102, P=0.023) and invasive mechanical ventilation (OR=4.62, 95％CI:1.478-14.444, P=0.008). Conclusions During the same hospital stay, the prevalence of non-HIV-PJP patients complicated with cytomegaloviremia was higher, and the independent risk factors were female, coinfection of fungal, and invasive mechanical ventilation.
